BDBM231042 US9340549, 61

SMILES: CC1(C)OC(=O)N([C@H]1c1ccc(F)cc1)[C@H]1CC[C@@H](CC1)n1c2ccc(cc2[nH]c1=O)C#N

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 231042   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tankyrase-1 (Homo sapiens (Human))	BDBM231042 (US9340549, 61) Show SMILES CC1(C)OC(=O)N([C@H]1c1ccc(F)cc1)[C@H]1CC[C@@H](CC1)n1c2ccc(cc2[nH]c1=O)C#N |r,wU:7.8,18.23,wD:15.16,(-7.62,.77,;-6.28,1.54,;-7.05,.2,;-6.28,3.08,;-4.82,3.55,;-4.05,4.89,;-3.91,2.31,;-4.82,1.06,;-4.42,-.43,;-5.51,-1.51,;-5.11,-3,;-3.62,-3.4,;-3.23,-4.89,;-2.53,-2.31,;-2.93,-.82,;-2.37,2.31,;-1.6,.97,;-.06,.97,;.71,2.31,;-.06,3.64,;-1.6,3.64,;2.25,2.31,;3.15,1.06,;2.83,-.44,;3.98,-1.47,;5.44,-1,;5.76,.51,;4.62,1.54,;4.62,3.08,;3.15,3.55,;2.38,4.89,;6.58,-2.03,;7.73,-3.06,)| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.42	n/a	n/a	n/a	n/a	n/a	25
AMGEN INC. US Patent					Assay Description The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...				US Patent US9340549 (2016) BindingDB Entry DOI: 10.7270/Q2SN07VD
					More data for this Ligand-Target Pair