null

SMILES: CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2cc[nH]c2n1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 231122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] (Homo sapiens (Human))	BDBM231122 (US9340549, 147) Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2cc[nH]c2n1 |r,wU:7.8,17.22,wD:14.15,(-8.46,-.59,;-7.13,.18,;-7.9,-1.16,;-7.13,1.72,;-5.66,2.19,;-4.89,3.53,;-4.76,.95,;-5.66,-.3,;-5.26,-1.79,;-6.35,-2.87,;-5.95,-4.36,;-4.47,-4.76,;-3.38,-3.67,;-3.78,-2.18,;-3.22,.95,;-2.45,-.39,;-.91,-.39,;-.14,.95,;-.91,2.28,;-2.45,2.28,;1.4,.95,;2.17,2.28,;1.4,3.62,;3.71,2.28,;4.48,.95,;6.02,.95,;6.79,2.28,;8.3,2.6,;8.46,4.13,;7.05,4.76,;6.02,3.62,;4.48,3.62,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.4	n/a	n/a	n/a	n/a	n/a	25
AMGEN INC. US Patent					Assay Description The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...				US Patent US9340549 (2016) BindingDB Entry DOI: 10.7270/Q2SN07VD
					More data for this Ligand-Target Pair