BDBM231622 PT170::US10071965, Compound PT170

SMILES: Cc1ccn(Cc2ccccc2Cl)c(=O)c1

InChI Key: InChIKey=GJNBCNBZMGOQOW-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 231622   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NADPH-dependent enoyl-ACP reductase (FabI) (Staphylococcus aureus)	BDBM231622 (PT170 | US10071965, Compound PT170) Show SMILES Cc1ccn(Cc2ccccc2Cl)c(=O)c1 Show InChI InChI=1S/C13H12ClNO/c1-10-6-7-15(13(16)8-10)9-11-4-2-3-5-12(11)14/h2-8H,9H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	229	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
University of Wuerzburg					Assay Description Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...				J Biol Chem 289: 15987-6005 (2014) Article DOI: 10.1074/jbc.M113.532804 BindingDB Entry DOI: 10.7270/Q2H41Q89
					More data for this Ligand-Target Pair
Enoyl-ACP Reductase (FabI) (Staphylococcus aureus)	BDBM231622 (PT170 | US10071965, Compound PT170) Show SMILES Cc1ccn(Cc2ccccc2Cl)c(=O)c1 Show InChI InChI=1S/C13H12ClNO/c1-10-6-7-15(13(16)8-10)9-11-4-2-3-5-12(11)14/h2-8H,9H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	229	-9.05	n/a	n/a	n/a	n/a	n/a	7.5	25
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK US Patent					Assay Description 10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...				US Patent US10071965 (2018) BindingDB Entry DOI: 10.7270/Q2D79DFZ
					More data for this Ligand-Target Pair
Enoyl-ACP Reductase (FabI) (Staphylococcus aureus)	BDBM231622 (PT170 | US10071965, Compound PT170) Show SMILES Cc1ccn(Cc2ccccc2Cl)c(=O)c1 Show InChI InChI=1S/C13H12ClNO/c1-10-6-7-15(13(16)8-10)9-11-4-2-3-5-12(11)14/h2-8H,9H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	849	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK US Patent					Assay Description Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...				US Patent US10071965 (2018) BindingDB Entry DOI: 10.7270/Q2D79DFZ
					More data for this Ligand-Target Pair