BDBM232356 US9346794, 62

SMILES: CC(C)n1cc(C(=O)NCc2ccc(c[n+]2[O-])S(C)(=O)=NC#N)c(=O)c(c1C)-c1cccc(c1)C(F)(F)F

InChI Key: InChIKey=QNHIWQVRUJUWIA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 232356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukocyte elastase (Homo sapiens (Human))	BDBM232356 (US9346794, 62) Show SMILES CC(C)n1cc(C(=O)NCc2ccc(c[n+]2[O-])S(C)(=O)=NC#N)c(=O)c(c1C)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H24F3N5O4S/c1-15(2)32-13-21(23(34)22(16(32)3)17-6-5-7-18(10-17)25(26,27)28)24(35)30-11-19-8-9-20(12-33(19)36)38(4,37)31-14-29/h5-10,12-13,15H,11H2,1-4H3,(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The following buffers were used: Compound buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5; Assay buffer: 100 mM Tris, 500 mM NaCl, adjusted to p...				US Patent US9346794 (2016) BindingDB Entry DOI: 10.7270/Q2X63KSJ
					More data for this Ligand-Target Pair