BDBM232750 US9346815, 296::US9604984, Example 296

SMILES: CN[C@@H]1CCC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F

InChI Key: InChIKey=PVUAOPLNCARIEI-CABCVRRESA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 232750   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232750 (US9346815, 296 | US9604984, Example 296) Show SMILES CN[C@@H]1CCC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F |r| Show InChI InChI=1S/C24H25ClF2N8O2/c1-29-14-4-2-5-15(11-14)35-12-17(20(32-35)16-10-13(25)6-7-18(16)37-24(26)27)31-23(36)19-21(28)33-34-9-3-8-30-22(19)34/h3,6-10,12,14-15,24,29H,2,4-5,11H2,1H3,(H2,28,33)(H,31,36)/t14-,15+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232750 (US9346815, 296 | US9604984, Example 296) Show SMILES CN[C@@H]1CCC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F |r| Show InChI InChI=1S/C24H25ClF2N8O2/c1-29-14-4-2-5-15(11-14)35-12-17(20(32-35)16-10-13(25)6-7-18(16)37-24(26)27)31-23(36)19-21(28)33-34-9-3-8-30-22(19)34/h3,6-10,12,14-15,24,29H,2,4-5,11H2,1H3,(H2,28,33)(H,31,36)/t14-,15+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232750 (US9346815, 296 | US9604984, Example 296) Show SMILES CN[C@@H]1CCC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F |r| Show InChI InChI=1S/C24H25ClF2N8O2/c1-29-14-4-2-5-15(11-14)35-12-17(20(32-35)16-10-13(25)6-7-18(16)37-24(26)27)31-23(36)19-21(28)33-34-9-3-8-30-22(19)34/h3,6-10,12,14-15,24,29H,2,4-5,11H2,1H3,(H2,28,33)(H,31,36)/t14-,15+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232750 (US9346815, 296 | US9604984, Example 296) Show SMILES CN[C@@H]1CCC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F |r| Show InChI InChI=1S/C24H25ClF2N8O2/c1-29-14-4-2-5-15(11-14)35-12-17(20(32-35)16-10-13(25)6-7-18(16)37-24(26)27)31-23(36)19-21(28)33-34-9-3-8-30-22(19)34/h3,6-10,12,14-15,24,29H,2,4-5,11H2,1H3,(H2,28,33)(H,31,36)/t14-,15+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	-12.9	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair