BDBM232767 US9346815, 313::US9604984, Example 313

SMILES: FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12

InChI Key: InChIKey=FYHCKMYRLLPAKO-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 232767   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232767 (US9346815, 313 | US9604984, Example 313) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232767 (US9346815, 313 | US9604984, Example 313) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232767 (US9346815, 313 | US9604984, Example 313) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232767 (US9346815, 313 | US9604984, Example 313) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair