null

SMILES: NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1

InChI Key: InChIKey=OTGOSPHNYNSXLY-YMZYAJTMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM234338 (4-Benzoyl-1-(4-((2-hydroxynaphthalen-1-yl)diazenyl...) Show SMILES NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1 Show InChI InChI=1S/C35H24N8O5S2/c36-50(47,48)35-41-40-34(49-35)37-33(46)30-28(32(45)23-12-5-2-6-13-23)31(22-10-3-1-4-11-22)43(42-30)25-18-16-24(17-19-25)38-39-29-26-14-8-7-9-21(26)15-20-27(29)44/h1-20,44H,(H2,36,47,48)(H,37,40,46)/b39-38+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University					Assay Description Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...				J Enzyme Inhib Med Chem 26: 231-7 (2011) Article DOI: 10.3109/14756366.2010.491795 BindingDB Entry DOI: 10.7270/Q2DZ0754
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM234338 (4-Benzoyl-1-(4-((2-hydroxynaphthalen-1-yl)diazenyl...) Show SMILES NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1 Show InChI InChI=1S/C35H24N8O5S2/c36-50(47,48)35-41-40-34(49-35)37-33(46)30-28(32(45)23-12-5-2-6-13-23)31(22-10-3-1-4-11-22)43(42-30)25-18-16-24(17-19-25)38-39-29-26-14-8-7-9-21(26)15-20-27(29)44/h1-20,44H,(H2,36,47,48)(H,37,40,46)/b39-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University					Assay Description Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...				J Enzyme Inhib Med Chem 26: 231-7 (2011) Article DOI: 10.3109/14756366.2010.491795 BindingDB Entry DOI: 10.7270/Q2DZ0754
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM234338 (4-Benzoyl-1-(4-((2-hydroxynaphthalen-1-yl)diazenyl...) Show SMILES NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1 Show InChI InChI=1S/C35H24N8O5S2/c36-50(47,48)35-41-40-34(49-35)37-33(46)30-28(32(45)23-12-5-2-6-13-23)31(22-10-3-1-4-11-22)43(42-30)25-18-16-24(17-19-25)38-39-29-26-14-8-7-9-21(26)15-20-27(29)44/h1-20,44H,(H2,36,47,48)(H,37,40,46)/b39-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	848	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University					Assay Description The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; Bülbül et al., J. Enzyme I...				J Enzyme Inhib Med Chem 26: 231-7 (2011) Article DOI: 10.3109/14756366.2010.491795 BindingDB Entry DOI: 10.7270/Q2DZ0754
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM234338 (4-Benzoyl-1-(4-((2-hydroxynaphthalen-1-yl)diazenyl...) Show SMILES NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1 Show InChI InChI=1S/C35H24N8O5S2/c36-50(47,48)35-41-40-34(49-35)37-33(46)30-28(32(45)23-12-5-2-6-13-23)31(22-10-3-1-4-11-22)43(42-30)25-18-16-24(17-19-25)38-39-29-26-14-8-7-9-21(26)15-20-27(29)44/h1-20,44H,(H2,36,47,48)(H,37,40,46)/b39-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.4	n/a
Dumlupinar University					Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...				J Enzyme Inhib Med Chem 26: 231-7 (2011) Article DOI: 10.3109/14756366.2010.491795 BindingDB Entry DOI: 10.7270/Q2DZ0754
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM234338 (4-Benzoyl-1-(4-((2-hydroxynaphthalen-1-yl)diazenyl...) Show SMILES NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1 Show InChI InChI=1S/C35H24N8O5S2/c36-50(47,48)35-41-40-34(49-35)37-33(46)30-28(32(45)23-12-5-2-6-13-23)31(22-10-3-1-4-11-22)43(42-30)25-18-16-24(17-19-25)38-39-29-26-14-8-7-9-21(26)15-20-27(29)44/h1-20,44H,(H2,36,47,48)(H,37,40,46)/b39-38+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University					Assay Description The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; Bülbül et al., J. Enzyme I...				J Enzyme Inhib Med Chem 26: 231-7 (2011) Article DOI: 10.3109/14756366.2010.491795 BindingDB Entry DOI: 10.7270/Q2DZ0754
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM234338 (4-Benzoyl-1-(4-((2-hydroxynaphthalen-1-yl)diazenyl...) Show SMILES NS(=O)(=O)c1nnc(NC(=O)c2nn(c(c2C(=O)c2ccccc2)-c2ccccc2)-c2ccc(cc2)\N=N\c2c(O)ccc3ccccc23)s1 Show InChI InChI=1S/C35H24N8O5S2/c36-50(47,48)35-41-40-34(49-35)37-33(46)30-28(32(45)23-12-5-2-6-13-23)31(22-10-3-1-4-11-22)43(42-30)25-18-16-24(17-19-25)38-39-29-26-14-8-7-9-21(26)15-20-27(29)44/h1-20,44H,(H2,36,47,48)(H,37,40,46)/b39-38+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.75E+3	n/a	n/a	n/a	n/a	7.4	n/a
Dumlupinar University					Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...				J Enzyme Inhib Med Chem 26: 231-7 (2011) Article DOI: 10.3109/14756366.2010.491795 BindingDB Entry DOI: 10.7270/Q2DZ0754
					More data for this Ligand-Target Pair