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SMILES: COC(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCc2ccc3ccccc3c2)c1

InChI Key: InChIKey=RBSUCNUKTNDLBX-REWPJTCUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23467   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q]


(Homo sapiens (Human))		BDBM23467
PNG
(hydroxamate deriv., 59 | methyl (1R,2R)-2-(hydroxy...)
Show SMILES COC(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCc2ccc3ccccc3c2)c1 |r|
Show InChI InChI=1S/C23H21NO5/c1-28-22(26)23(13-20(23)21(25)24-27)18-7-4-8-19(12-18)29-14-15-9-10-16-5-2-3-6-17(16)11-15/h2-12,20,27H,13-14H2,1H3,(H,24,25)/t20-,23-/m0/s1
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MMDB

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Article
PubMed
 3.00E+3 -7.45n/an/an/an/an/a7.322



Schering-Plough Research Institute



Assay Description
Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...

J Med Chem 51: 725-36 (2008)


Article DOI: 10.1021/jm070376o
BindingDB Entry DOI: 10.7270/Q2Q23XKR
More data for this
Ligand-Target Pair