BDBM23479 (1R,2R)-2-N-hydroxy-1-N,1-N-dimethyl-1-{3-[(2-methylquinolin-4-yl)methoxy]phenyl}cyclopropane-1,2-dicarboxamide::hydroxamate deriv., 71

SMILES: CN(C)C(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCc2cc(C)nc3ccccc23)c1

InChI Key: InChIKey=NBJXSJRESIAPEZ-RDPSFJRHSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q] (Homo sapiens (Human))	BDBM23479 ((1R,2R)-2-N-hydroxy-1-N,1-N-dimethyl-1-{3-[(2-meth...) Show SMILES CN(C)C(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCc2cc(C)nc3ccccc23)c1 |r| Show InChI InChI=1S/C24H25N3O4/c1-15-11-16(19-9-4-5-10-21(19)25-15)14-31-18-8-6-7-17(12-18)24(23(29)27(2)3)13-20(24)22(28)26-30/h4-12,20,30H,13-14H2,1-3H3,(H,26,28)/t20-,24-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2.70E+3	-7.52	n/a	n/a	n/a	n/a	n/a	7.3	22
Schering-Plough Research Institute					Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...				J Med Chem 51: 725-36 (2008) Article DOI: 10.1021/jm070376o BindingDB Entry DOI: 10.7270/Q2Q23XKR
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