BDBM23483 (1R,2R)-N-hydroxy-2-[(4-methylpiperazin-1-yl)carbonyl]-2-{3-[(2-methylquinolin-4-yl)methoxy]phenyl}cyclopropane-1-carboxamide::hydroxamate deriv., 75

SMILES: CN1CCN(CC1)C(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCc2cc(C)nc3ccccc23)c1

InChI Key: InChIKey=XACGDVHRXILWLO-HOFKKMOUSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q] (Homo sapiens (Human))	BDBM23483 ((1R,2R)-N-hydroxy-2-[(4-methylpiperazin-1-yl)carbo...) Show SMILES CN1CCN(CC1)C(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCc2cc(C)nc3ccccc23)c1 |r| Show InChI InChI=1S/C27H30N4O4/c1-18-14-19(22-8-3-4-9-24(22)28-18)17-35-21-7-5-6-20(15-21)27(16-23(27)25(32)29-34)26(33)31-12-10-30(2)11-13-31/h3-9,14-15,23,34H,10-13,16-17H2,1-2H3,(H,29,32)/t23-,27-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...				J Med Chem 51: 725-36 (2008) Article DOI: 10.1021/jm070376o BindingDB Entry DOI: 10.7270/Q2Q23XKR
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