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SMILES: COC(=O)[C@@]1(Cc2ccc(OCCc3cccc4ccccc34)cc2)C[C@@H]1C(=O)NO

InChI Key: InChIKey=KVMLUEIAXXNHKM-RDGATRHJSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23492   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q]


(Homo sapiens (Human))		BDBM23492
PNG
(hydroxamate deriv., 83 | methyl (1R,2S)-2-(hydroxy...)
Show SMILES COC(=O)[C@@]1(Cc2ccc(OCCc3cccc4ccccc34)cc2)C[C@@H]1C(=O)NO |r|
Show InChI InChI=1S/C25H25NO5/c1-30-24(28)25(16-22(25)23(27)26-29)15-17-9-11-20(12-10-17)31-14-13-19-7-4-6-18-5-2-3-8-21(18)19/h2-12,22,29H,13-16H2,1H3,(H,26,27)/t22-,25+/m1/s1
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Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute



Assay Description
Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...

J Med Chem 51: 725-36 (2008)


Article DOI: 10.1021/jm070376o
BindingDB Entry DOI: 10.7270/Q2Q23XKR
More data for this
Ligand-Target Pair