BDBM235033 US9556168, 10C

SMILES: OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C(F)(F)F)c3cc(cc(F)c23)C(=O)N2CCC2)c(F)c1

InChI Key: InChIKey=HYEIELMRFQPSKL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 235033   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM235033 (US9556168, 10C) Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C(F)(F)F)c3cc(cc(F)c23)C(=O)N2CCC2)c(F)c1 Show InChI InChI=1S/C26H17ClF5N3O3/c27-18-4-1-3-17(26(30,31)32)16(18)12-35-21-11-14(24(36)34-7-2-8-34)10-20(29)22(21)23(33-35)15-6-5-13(25(37)38)9-19(15)28/h1,3-6,9-11H,2,7-8,12H2,(H,37,38)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...				US Patent US9556168 (2017) BindingDB Entry DOI: 10.7270/Q2D220MV
					More data for this Ligand-Target Pair