BDBM23625 2-({6-[(2-hydroxyethyl)amino]-4,8-bis(morpholin-4-yl)pyrimido[5,4-d][1,3]diazin-2-yl}amino)ethan-1-ol::Dipyridamole Analogue, 5

SMILES: OCCNc1nc(N2CCOCC2)c2nc(NCCO)nc(N3CCOCC3)c2n1

InChI Key: InChIKey=LOLWOFFZNLGXFZ-UHFFFAOYSA-N

Data: 1 Other

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23625   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Equilibrative Nucleoside Transporter 1 (ENT1) (Homo sapiens (Human))	BDBM23625 (2-({6-[(2-hydroxyethyl)amino]-4,8-bis(morpholin-4-...) Show SMILES OCCNc1nc(N2CCOCC2)c2nc(NCCO)nc(N3CCOCC3)c2n1 Show InChI InChI=1S/C18H28N8O4/c27-7-1-19-17-21-13-14(15(23-17)25-3-9-29-10-4-25)22-18(20-2-8-28)24-16(13)26-5-11-30-12-6-26/h27-28H,1-12H2,(H,19,21,23)(H,20,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.4	22
University of Tennessee Health Science Center					Assay Description The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...				J Med Chem 50: 3906-20 (2007) Article DOI: 10.1021/jm070311l BindingDB Entry DOI: 10.7270/Q2XK8CVN
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