BDBM23627 Dipyridamole Analogue, 7::tert-butyl 4-{2,6-bis[bis(2-hydroxyethyl)amino]-8-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}pyrimido[5,4-d][1,3]diazin-4-yl}piperazine-1-carboxylate
SMILES: CC(C)(C)OC(=O)N1CCN(CC1)c1nc(nc2c(nc(nc12)N(CCO)CCO)N1CCN(CC1)C(=O)OC(C)(C)C)N(CCO)CCO
InChI Key: InChIKey=BUMXXHLAFAUMLK-UHFFFAOYSA-N
Data: 1 Other
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Equilibrative Nucleoside Transporter 1 (ENT1) (Homo sapiens (Human)) | BDBM23627 (Dipyridamole Analogue, 7 | tert-butyl 4-{2,6-bis[b...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i... | J Med Chem 50: 3906-20 (2007) Article DOI: 10.1021/jm070311l BindingDB Entry DOI: 10.7270/Q2XK8CVN | |||||||||||
More data for this Ligand-Target Pair |