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BDBM23656 2-{[4,8-bis(dibenzylamino)-6-[(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl]amino}ethan-1-ol::Dipyridamole Analogue, 38

SMILES: OCCNc1nc(N(Cc2ccccc2)Cc2ccccc2)c2nc(NCCO)nc(N(Cc3ccccc3)Cc3ccccc3)c2n1

InChI Key: InChIKey=XUYPNFXSWRIXCO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23656   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23656
PNG
(2-{[4,8-bis(dibenzylamino)-6-[(2-hydroxyethyl)amin...)
Show SMILES OCCNc1nc(N(Cc2ccccc2)Cc2ccccc2)c2nc(NCCO)nc(N(Cc3ccccc3)Cc3ccccc3)c2n1
Show InChI InChI=1S/C38H40N8O2/c47-23-21-39-37-42-34-33(35(43-37)45(25-29-13-5-1-6-14-29)26-30-15-7-2-8-16-30)41-38(40-22-24-48)44-36(34)46(27-31-17-9-3-10-18-31)28-32-19-11-4-12-20-32/h1-20,47-48H,21-28H2,(H,39,42,43)(H,40,41,44)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair