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BDBM23671 2-{[4,8-bis(tert-butylamino)-6-[(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl]amino}ethan-1-ol::Dipyridamole Analogue, 53

SMILES: CC(C)(C)Nc1nc(NCCO)nc2c(NC(C)(C)C)nc(NCCO)nc12

InChI Key: InChIKey=ZHAGPFXYLKIVAC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23671   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23671
PNG
(2-{[4,8-bis(tert-butylamino)-6-[(2-hydroxyethyl)am...)
Show SMILES CC(C)(C)Nc1nc(NCCO)nc2c(NC(C)(C)C)nc(NCCO)nc12
Show InChI InChI=1S/C18H32N8O2/c1-17(2,3)25-13-11-12(22-15(23-13)19-7-9-27)14(26-18(4,5)6)24-16(21-11)20-8-10-28/h27-28H,7-10H2,1-6H3,(H2,19,22,23,25)(H2,20,21,24,26)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair