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BDBM23681 2-{[4,8-bis(cyclobutylamino)-6-[(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl]amino}ethan-1-ol::Dipyridamole Analogue, 63

SMILES: OCCNc1nc(NC2CCC2)c2nc(NCCO)nc(NC3CCC3)c2n1

InChI Key: InChIKey=ZXTCSOMOOKZHDI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23681   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23681
PNG
(2-{[4,8-bis(cyclobutylamino)-6-[(2-hydroxyethyl)am...)
Show SMILES OCCNc1nc(NC2CCC2)c2nc(NCCO)nc(NC3CCC3)c2n1
Show InChI InChI=1S/C18H28N8O2/c27-9-7-19-17-24-14-13(15(25-17)21-11-3-1-4-11)23-18(20-8-10-28)26-16(14)22-12-5-2-6-12/h11-12,27-28H,1-10H2,(H2,19,21,24,25)(H2,20,22,23,26)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair