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BDBM23683 2-{[4,8-bis(cyclopentylamino)-6-[(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl]amino}ethan-1-ol::Dipyridamole Analogue, 65

SMILES: OCCNc1nc(NC2CCCC2)c2nc(NCCO)nc(NC3CCCC3)c2n1

InChI Key: InChIKey=JVVFBBZNWPJCNL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23683   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23683
PNG
(2-{[4,8-bis(cyclopentylamino)-6-[(2-hydroxyethyl)a...)
Show SMILES OCCNc1nc(NC2CCCC2)c2nc(NCCO)nc(NC3CCCC3)c2n1
Show InChI InChI=1S/C20H32N8O2/c29-11-9-21-19-26-16-15(17(27-19)23-13-5-1-2-6-13)25-20(22-10-12-30)28-18(16)24-14-7-3-4-8-14/h13-14,29-30H,1-12H2,(H2,21,23,26,27)(H2,22,24,25,28)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair