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BDBM23686 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(phenylamino)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol::Dipyridamole Analogue, 68

SMILES: OCCN(CCO)c1nc(Nc2ccccc2)c2nc(nc(Nc3ccccc3)c2n1)N(CCO)CCO

InChI Key: InChIKey=UHDLKSBBQUDJNR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23686   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23686
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(phenylami...)
Show SMILES OCCN(CCO)c1nc(Nc2ccccc2)c2nc(nc(Nc3ccccc3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C26H32N8O4/c35-15-11-33(12-16-36)25-30-22-21(23(31-25)27-19-7-3-1-4-8-19)29-26(34(13-17-37)14-18-38)32-24(22)28-20-9-5-2-6-10-20/h1-10,35-38H,11-18H2,(H,27,30,31)(H,28,29,32)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair