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BDBM23688 2-{[4,8-bis(benzylamino)-6-[bis(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl](2-hydroxyethyl)amino}ethan-1-ol::Dipyridamole Analogue, 70

SMILES: OCCN(CCO)c1nc(NCc2ccccc2)c2nc(nc(NCc3ccccc3)c2n1)N(CCO)CCO

InChI Key: InChIKey=DALNANYIXSHRKJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23688   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23688
PNG
(2-{[4,8-bis(benzylamino)-6-[bis(2-hydroxyethyl)ami...)
Show SMILES OCCN(CCO)c1nc(NCc2ccccc2)c2nc(nc(NCc3ccccc3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C28H36N8O4/c37-15-11-35(12-16-38)27-32-24-23(25(33-27)29-19-21-7-3-1-4-8-21)31-28(36(13-17-39)14-18-40)34-26(24)30-20-22-9-5-2-6-10-22/h1-10,37-40H,11-20H2,(H,29,32,33)(H,30,31,34)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair