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BDBM23689 2-{[4,8-bis(benzylamino)-6-[(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl]amino}ethan-1-ol::Dipyridamole Analogue, 71

SMILES: OCCNc1nc(NCc2ccccc2)c2nc(NCCO)nc(NCc3ccccc3)c2n1

InChI Key: InChIKey=RFIXOEOHIAUALA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23689   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))		BDBM23689
PNG
(2-{[4,8-bis(benzylamino)-6-[(2-hydroxyethyl)amino]...)
Show SMILES OCCNc1nc(NCc2ccccc2)c2nc(NCCO)nc(NCc3ccccc3)c2n1
Show InChI InChI=1S/C24H28N8O2/c33-13-11-25-23-30-20-19(21(31-23)27-15-17-7-3-1-4-8-17)29-24(26-12-14-34)32-22(20)28-16-18-9-5-2-6-10-18/h1-10,33-34H,11-16H2,(H2,25,27,30,31)(H2,26,28,29,32)
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Similars
Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Tennessee Health Science Center



Assay Description
The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...

J Med Chem 50: 3906-20 (2007)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2XK8CVN
More data for this
Ligand-Target Pair