BDBM236905 US9388176, 140

SMILES: CSc1ncc2CN(CCc2n1)c1cc(C)cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=RASKDAOZLIHQCQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 236905   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM236905 (US9388176, 140) Show SMILES CSc1ncc2CN(CCc2n1)c1cc(C)cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H21F3N4OS/c1-14-8-15(21(31)28-18-5-3-4-17(11-18)23(24,25)26)10-19(9-14)30-7-6-20-16(13-30)12-27-22(29-20)32-2/h3-5,8-12H,6-7,13H2,1-2H3,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair