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SMILES: FC(F)(F)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cnc2ccnn32)c1

InChI Key: InChIKey=DFFRQPFUNWMMEA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 236912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM236912 (US9388181, 4) Show SMILES FC(F)(F)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cnc2ccnn32)c1 Show InChI InChI=1S/C23H18F3N5O/c24-23(25,26)17-4-2-5-18(12-17)29-22(32)15-3-1-6-19(11-15)30-10-8-20-16(14-30)13-27-21-7-9-28-31(20)21/h1-7,9,11-13H,8,10,14H2,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US9388181 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57QP
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM236912 (US9388181, 4) Show SMILES FC(F)(F)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cnc2ccnn32)c1 Show InChI InChI=1S/C23H18F3N5O/c24-23(25,26)17-4-2-5-18(12-17)29-22(32)15-3-1-6-19(11-15)30-10-8-20-16(14-30)13-27-21-7-9-28-31(20)21/h1-7,9,11-13H,8,10,14H2,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	37
Allergan, Inc. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF-induced increases in intracellular calcium l...				US Patent US9388181 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57QP
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM236912 (US9388181, 4) Show SMILES FC(F)(F)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cnc2ccnn32)c1 Show InChI InChI=1S/C23H18F3N5O/c24-23(25,26)17-4-2-5-18(12-17)29-22(32)15-3-1-6-19(11-15)30-10-8-20-16(14-30)13-27-21-7-9-28-31(20)21/h1-7,9,11-13H,8,10,14H2,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...				US Patent US9388181 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57QP
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM236912 (US9388181, 4) Show SMILES FC(F)(F)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cnc2ccnn32)c1 Show InChI InChI=1S/C23H18F3N5O/c24-23(25,26)17-4-2-5-18(12-17)29-22(32)15-3-1-6-19(11-15)30-10-8-20-16(14-30)13-27-21-7-9-28-31(20)21/h1-7,9,11-13H,8,10,14H2,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	37
Allergan, Inc. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...				US Patent US9388181 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57QP
					More data for this Ligand-Target Pair