BDBM237878 US9394282, 9-13

SMILES: NC(=O)c1cn(nc1Nc1ccc(Cl)c(F)c1)[C@@H]1COCC[C@H]1C#N

InChI Key: InChIKey=HXAPBPDFLXXIAB-LKFCYVNXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 237878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM237878 (US9394282, 9-13) Show SMILES NC(=O)c1cn(nc1Nc1ccc(Cl)c(F)c1)[C@@H]1COCC[C@H]1C#N |r| Show InChI InChI=1S/C16H15ClFN5O2/c17-12-2-1-10(5-13(12)18)21-16-11(15(20)24)7-23(22-16)14-8-25-4-3-9(14)6-19/h1-2,5,7,9,14H,3-4,8H2,(H2,20,24)(H,21,22)/t9-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM237878 (US9394282, 9-13) Show SMILES NC(=O)c1cn(nc1Nc1ccc(Cl)c(F)c1)[C@@H]1COCC[C@H]1C#N |r| Show InChI InChI=1S/C16H15ClFN5O2/c17-12-2-1-10(5-13(12)18)21-16-11(15(20)24)7-23(22-16)14-8-25-4-3-9(14)6-19/h1-2,5,7,9,14H,3-4,8H2,(H2,20,24)(H,21,22)/t9-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair