BDBM238120 US9394289, 16

SMILES: COC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=RYHRSJWRYLDPMI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238120   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM238120 (US9394289, 16) Show SMILES COC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29| Show InChI InChI=1S/C26H30N4O4/c1-25(2)8-6-17(7-9-25)20-14-18(26(24(32)33-3)10-12-34-13-11-26)4-5-21(20)30-23(31)22-28-16-19(15-27)29-22/h4-6,14,16H,7-13H2,1-3H3,(H,28,29)(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	7.5	25
Janssen Pharmaceutica NV US Patent					Assay Description An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...				US Patent US9394289 (2016) BindingDB Entry DOI: 10.7270/Q28K780X
					More data for this Ligand-Target Pair