BDBM238338 US9394273, 27::US9394273, 28

SMILES: OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O

InChI Key: InChIKey=HNZZMMKIJHPUAD-WIPJZLDNSA-N

Data: 4 KI  5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 238338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	457	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.63E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	7.4	25
ALLERGAN, INC. US Patent					Assay Description A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA ce...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.99E+3	n/a	n/a	7.4	n/a
ALLERGAN, INC. US Patent					Assay Description Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in Biocoati® Poly-D-lysine-coated black-wall, clear-bott...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	7.4	25
ALLERGAN, INC. US Patent					Assay Description A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA ce...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	125	n/a	n/a	7.4	25
ALLERGAN, INC. US Patent					Assay Description A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA ce...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM238338 (US9394273, 27 | US9394273, 28) Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	18	n/a	n/a	7.4	25
ALLERGAN, INC. US Patent					Assay Description A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA ce...				US Patent US9394273 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
					More data for this Ligand-Target Pair