BDBM238355 3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1c)

SMILES: CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl

InChI Key: InChIKey=BBNCOFALSNZADW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 238355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Saccharomyces cerevisiae (Baker's yeast))	BDBM238355 (3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)| Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta (Trypanosoma brucei brucei)	BDBM238355 (3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)| Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM238355 (3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)| Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair