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SMILES: CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1

InChI Key: InChIKey=JXTNSWUVLITLAJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 238525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238525 (US9394297, 159) Show SMILES CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C20H23N5O/c1-3-4-9-21-19-12(2)23-16-7-5-6-13(18(16)25-19)17-11-14-15(24-17)8-10-22-20(14)26/h5-7,11,24H,3-4,8-10H2,1-2H3,(H,21,25)(H,22,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238525 (US9394297, 159) Show SMILES CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C20H23N5O/c1-3-4-9-21-19-12(2)23-16-7-5-6-13(18(16)25-19)17-11-14-15(24-17)8-10-22-20(14)26/h5-7,11,24H,3-4,8-10H2,1-2H3,(H,21,25)(H,22,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...				ACS Med Chem Lett 7: 408-12 (2016) BindingDB Entry DOI: 10.7270/Q2MG7RD5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238525 (US9394297, 159) Show SMILES CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C20H23N5O/c1-3-4-9-21-19-12(2)23-16-7-5-6-13(18(16)25-19)17-11-14-15(24-17)8-10-22-20(14)26/h5-7,11,24H,3-4,8-10H2,1-2H3,(H,21,25)(H,22,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...				ACS Med Chem Lett 7: 408-12 (2016) BindingDB Entry DOI: 10.7270/Q2MG7RD5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238525 (US9394297, 159) Show SMILES CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C20H23N5O/c1-3-4-9-21-19-12(2)23-16-7-5-6-13(18(16)25-19)17-11-14-15(24-17)8-10-22-20(14)26/h5-7,11,24H,3-4,8-10H2,1-2H3,(H,21,25)(H,22,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair