null

SMILES: C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O

InChI Key: InChIKey=GTKNYUJNLDGSDF-SECBINFHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 238724   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238724 (US9394297, 405) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238724 (US9394297, 405) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238724 (US9394297, 405) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238724 (US9394297, 405) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM238724 (US9394297, 405) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair