BDBM238899 US9403827, 1
SMILES: COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F
InChI Key: InChIKey=DRUCKCPJGULCLL-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p53-MDM2 (Homo sapiens (Human)) | BDBM238899 (US9403827, 1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p53-MDM2 (Homo sapiens (Human)) | BDBM238899 (US9403827, 1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 882 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p53-MDM4 (Homo sapiens (Human)) | BDBM238899 (US9403827, 1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair |