BDBM238908 US9403827, 10

SMILES: COc1ccc(cc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)N(C)C

InChI Key: InChIKey=AJIVOSOKWBCTKY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM238908 (US9403827, 10) Show SMILES COc1ccc(cc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)N(C)C Show InChI InChI=1S/C32H33Cl2N5O3/c1-17(2)38-28-27(23-12-11-21(33)14-19(23)4)39(25-16-22(34)10-8-18(25)3)32(41)36-29(28)35-30(38)24-15-20(31(40)37(5)6)9-13-26(24)42-7/h8-17,27H,1-7H3,(H,36,41)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	432	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair