BDBM239063 US10227295, Compound 10a::US9409858, 10a::US9956192, Compound 10a

SMILES: COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O

InChI Key: InChIKey=FOPVUBSEBZNOHJ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 239063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM239063 (US10227295, Compound 10a | US9409858, 10a | US9956...) Show SMILES COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O Show InChI InChI=1S/C20H21N3O5/c1-20(2)18(25)23(15-6-4-5-7-16(15)28-3)19(26)22(20)12-13-8-10-14(11-9-13)17(24)21-27/h4-11,27H,12H2,1-3H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a	8.0	n/a
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois US Patent					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				US Patent US9409858 (2016) BindingDB Entry DOI: 10.7270/Q21V5CWN
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM239063 (US10227295, Compound 10a | US9409858, 10a | US9956...) Show SMILES COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O Show InChI InChI=1S/C20H21N3O5/c1-20(2)18(25)23(15-6-4-5-7-16(15)28-3)19(26)22(20)12-13-8-10-14(11-9-13)17(24)21-27/h4-11,27H,12H2,1-3H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74.2	n/a	n/a	n/a	n/a	8.0	n/a
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois US Patent					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				US Patent US9409858 (2016) BindingDB Entry DOI: 10.7270/Q21V5CWN
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM239063 (US10227295, Compound 10a | US9409858, 10a | US9956...) Show SMILES COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O Show InChI InChI=1S/C20H21N3O5/c1-20(2)18(25)23(15-6-4-5-7-16(15)28-3)19(26)22(20)12-13-8-10-14(11-9-13)17(24)21-27/h4-11,27H,12H2,1-3H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74.2	n/a	n/a	n/a	n/a	n/a	n/a
KuDOS Pharmaceuticals Ltd.					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 6581-91 (2008) BindingDB Entry DOI: 10.7270/Q2BZ68CW
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM239063 (US10227295, Compound 10a | US9409858, 10a | US9956...) Show SMILES COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O Show InChI InChI=1S/C20H21N3O5/c1-20(2)18(25)23(15-6-4-5-7-16(15)28-3)19(26)22(20)12-13-8-10-14(11-9-13)17(24)21-27/h4-11,27H,12H2,1-3H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74.2	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 196-218 (2008) BindingDB Entry DOI: 10.7270/Q2VD71RF
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM239063 (US10227295, Compound 10a | US9409858, 10a | US9956...) Show SMILES COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O Show InChI InChI=1S/C20H21N3O5/c1-20(2)18(25)23(15-6-4-5-7-16(15)28-3)19(26)22(20)12-13-8-10-14(11-9-13)17(24)21-27/h4-11,27H,12H2,1-3H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
KuDOS Pharmaceuticals Ltd.					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 6581-91 (2008) BindingDB Entry DOI: 10.7270/Q2BZ68CW
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM239063 (US10227295, Compound 10a | US9409858, 10a | US9956...) Show SMILES COc1ccccc1N1C(=O)N(Cc2ccc(cc2)C(=O)NO)C(C)(C)C1=O Show InChI InChI=1S/C20H21N3O5/c1-20(2)18(25)23(15-6-4-5-7-16(15)28-3)19(26)22(20)12-13-8-10-14(11-9-13)17(24)21-27/h4-11,27H,12H2,1-3H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 196-218 (2008) BindingDB Entry DOI: 10.7270/Q2VD71RF
					More data for this Ligand-Target Pair