BDBM239651 US9394309, 107

SMILES: Cc1cc(C)c(cc1NC(=O)c1cc(F)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1

InChI Key: InChIKey=QORNIDMVCURULB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 239651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TIE-2 (Homo sapiens (Human))	BDBM239651 (US9394309, 107) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(F)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H19F6N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	9.6	4
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2 (Homo sapiens (Human))	BDBM239651 (US9394309, 107) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(F)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H19F6N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair