BDBM240645 US9409924, (3aR,5R,6R,7S,7aR)-2-(dimethylamino)-7-fluoro-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazol-6-ol
SMILES: CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1
InChI Key: InChIKey=JOKKFZJLPKIPOS-OZRXBMAMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) (Homo sapiens (Human)) | BDBM240645 (US9409924, (3aR,5R,6R,7S,7aR)-2-(dimethylamino)-7-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | -13.0 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet... | US Patent US9409924 (2016) BindingDB Entry DOI: 10.7270/Q26H4G90 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) (Homo sapiens (Human)) | BDBM240645 (US9409924, (3aR,5R,6R,7S,7aR)-2-(dimethylamino)-7-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ... | US Patent US9409924 (2016) BindingDB Entry DOI: 10.7270/Q26H4G90 | |||||||||||
More data for this Ligand-Target Pair |