BDBM240862 US9394331, 124

SMILES: COc1nc(N)nc2n(cnc12)C1OC(COP(=O)(N[C@@H](C)C(=O)OCC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1

InChI Key: InChIKey=LPVCKRYXKXQXSA-FXMYBSOZSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 240862   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RNA polymerase (NS5B) (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240862 (US9394331, 124) Show SMILES COc1nc(N)nc2n(cnc12)C1OC(COP(=O)(N[C@@H](C)C(=O)OCC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C26H35N6O9P/c1-15(2)12-37-23(34)16(3)31-42(35,41-17-8-6-5-7-9-17)39-13-18-20(33)26(10-11-38-26)24(40-18)32-14-28-19-21(32)29-25(27)30-22(19)36-4/h5-9,14-16,18,20,24,33H,10-13H2,1-4H3,(H,31,35)(H2,27,29,30)/t16-,18?,20+,24?,26+,42?/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	566	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
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