BDBM24110 2-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-amine::CHEMBL381599::tetrahydroisoquinoline (THIQ), 15

SMILES: Cc1ccc2C(CN(CCN)Cc2c1C)c1ccccc1

InChI Key: InChIKey=UQSPLCZWTHEZMX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM24110 (2-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...) Show SMILES Cc1ccc2C(CN(CCN)Cc2c1C)c1ccccc1 Show InChI InChI=1S/C19H24N2/c1-14-8-9-17-18(15(14)2)12-21(11-10-20)13-19(17)16-6-4-3-5-7-16/h3-9,19H,10-13,20H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 722-6 (2007) Article DOI: 10.1016/j.bmcl.2006.10.083 BindingDB Entry DOI: 10.7270/Q2HT2Q4S
					More data for this Ligand-Target Pair
Kinesin Spindle Protein Eg5 (Homo sapiens (Human))	BDBM24110 (2-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...) Show SMILES Cc1ccc2C(CN(CCN)Cc2c1C)c1ccccc1 Show InChI InChI=1S/C19H24N2/c1-14-8-9-17-18(15(14)2)12-21(11-10-20)13-19(17)16-6-4-3-5-7-16/h3-9,19H,10-13,20H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.27E+3	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).				Bioorg Med Chem Lett 16: 2095-100 (2006) Article DOI: 10.1016/j.bmcl.2006.01.056 BindingDB Entry DOI: 10.7270/Q2VM49KF
					More data for this Ligand-Target Pair