BDBM24146 7,8-dichloro-4-(3-hydroxyphenyl)-N,N-dimethyl-1,2,3,4-tetrahydroisoquinoline-2-carboxamide::tetrahydroisoquinoline (THIQ), 50

SMILES: CN(C)C(=O)N1CC(c2cccc(O)c2)c2ccc(Cl)c(Cl)c2C1

InChI Key: InChIKey=UMODMSWPONWCHE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24146   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kinesin Spindle Protein Eg5 (Homo sapiens (Human))	BDBM24146 (7,8-dichloro-4-(3-hydroxyphenyl)-N,N-dimethyl-1,2,...) Show SMILES CN(C)C(=O)N1CC(c2cccc(O)c2)c2ccc(Cl)c(Cl)c2C1 Show InChI InChI=1S/C18H18Cl2N2O2/c1-21(2)18(24)22-9-14(11-4-3-5-12(23)8-11)13-6-7-16(19)17(20)15(13)10-22/h3-8,14,23H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).				Bioorg Med Chem Lett 16: 2095-100 (2006) Article DOI: 10.1016/j.bmcl.2006.01.056 BindingDB Entry DOI: 10.7270/Q2VM49KF
					More data for this Ligand-Target Pair