BDBM241619 US9409915, 11::US9718820, Compound 11

SMILES: COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl

InChI Key: InChIKey=BWNRDOOTXFSNPN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 241619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241619 (US9409915, 11 | US9718820, Compound 11) Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl Show InChI InChI=1S/C21H21Cl2N5O/c1-21(2,3)18-15(23)17(28(4)27-18)19-24-14-10-13(11-8-6-7-9-12(11)22)25-20(29-5)16(14)26-19/h6-10H,1-5H3,(H,24,26)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...				US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241619 (US9409915, 11 | US9718820, Compound 11) Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl Show InChI InChI=1S/C21H21Cl2N5O/c1-21(2,3)18-15(23)17(28(4)27-18)19-24-14-10-13(11-8-6-7-9-12(11)22)25-20(29-5)16(14)26-19/h6-10H,1-5H3,(H,24,26)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...				US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ
					More data for this Ligand-Target Pair