BDBM242020 US9415055, N-[2-(4-Chloro-phenyl)-2-(4,4-difluoro-piperidin-1-yl)-ethyl]-2,3-dimethyl-benzamide::US9593105, 21

SMILES: Cc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2ccc(Cl)cc2)c1C

InChI Key: InChIKey=JTQVHGRELGUEGF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242020   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242020 (US9415055, N-[2-(4-Chloro-phenyl)-2-(4,4-difluoro-...) Show SMILES Cc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2ccc(Cl)cc2)c1C Show InChI InChI=1S/C22H25ClF2N2O/c1-15-4-3-5-19(16(15)2)21(28)26-14-20(17-6-8-18(23)9-7-17)27-12-10-22(24,25)11-13-27/h3-9,20H,10-14H2,1-2H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242020 (US9415055, N-[2-(4-Chloro-phenyl)-2-(4,4-difluoro-...) Show SMILES Cc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2ccc(Cl)cc2)c1C Show InChI InChI=1S/C22H25ClF2N2O/c1-15-4-3-5-19(16(15)2)21(28)26-14-20(17-6-8-18(23)9-7-17)27-12-10-22(24,25)11-13-27/h3-9,20H,10-14H2,1-2H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair