BDBM242030 US9415055, 2,3-dichloro-N-[2-morpholino-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]benzamide::US9593105, 36

SMILES: FC(F)(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCOCC1

InChI Key: InChIKey=AZBWLFIJIDNOJD-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 242030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242030 (US9415055, 2,3-dichloro-N-[2-morpholino-2-[2-(trif...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCOCC1 Show InChI InChI=1S/C18H17Cl2F3N4O2/c19-13-3-1-2-12(15(13)20)16(28)24-10-14(27-4-6-29-7-5-27)11-8-25-17(26-9-11)18(21,22)23/h1-3,8-9,14H,4-7,10H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242030 (US9415055, 2,3-dichloro-N-[2-morpholino-2-[2-(trif...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCOCC1 Show InChI InChI=1S/C18H17Cl2F3N4O2/c19-13-3-1-2-12(15(13)20)16(28)24-10-14(27-4-6-29-7-5-27)11-8-25-17(26-9-11)18(21,22)23/h1-3,8-9,14H,4-7,10H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242030 (US9415055, 2,3-dichloro-N-[2-morpholino-2-[2-(trif...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCOCC1 Show InChI InChI=1S/C18H17Cl2F3N4O2/c19-13-3-1-2-12(15(13)20)16(28)24-10-14(27-4-6-29-7-5-27)11-8-25-17(26-9-11)18(21,22)23/h1-3,8-9,14H,4-7,10H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242030 (US9415055, 2,3-dichloro-N-[2-morpholino-2-[2-(trif...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCOCC1 Show InChI InChI=1S/C18H17Cl2F3N4O2/c19-13-3-1-2-12(15(13)20)16(28)24-10-14(27-4-6-29-7-5-27)11-8-25-17(26-9-11)18(21,22)23/h1-3,8-9,14H,4-7,10H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair