BDBM242042 US9415055, 2-chloro-N-[2-(4,4-difluoro-1-piperidyl)-2-(6-fluoro-3-pyridyl)ethyl]benzamide::US9593105, 43

SMILES: Fc1ccc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCC(F)(F)CC1

InChI Key: InChIKey=HXZFPUXTLRZDBI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242042   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242042 (US9415055, 2-chloro-N-[2-(4,4-difluoro-1-piperidyl...) Show SMILES Fc1ccc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H19ClF3N3O/c20-15-4-2-1-3-14(15)18(27)25-12-16(13-5-6-17(21)24-11-13)26-9-7-19(22,23)8-10-26/h1-6,11,16H,7-10,12H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242042 (US9415055, 2-chloro-N-[2-(4,4-difluoro-1-piperidyl...) Show SMILES Fc1ccc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H19ClF3N3O/c20-15-4-2-1-3-14(15)18(27)25-12-16(13-5-6-17(21)24-11-13)26-9-7-19(22,23)8-10-26/h1-6,11,16H,7-10,12H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair