BDBM242070 US9415055, 2-chloro-N-[2-(4,4-difluoro-1-piperidyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]benzamide::US9593105, 71

SMILES: FC(F)(F)c1ncc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCC(F)(F)CC1

InChI Key: InChIKey=HCUYHRRITISEMJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242070   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242070 (US9415055, 2-chloro-N-[2-(4,4-difluoro-1-piperidyl...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H18ClF5N4O/c20-14-4-2-1-3-13(14)16(30)26-11-15(29-7-5-18(21,22)6-8-29)12-9-27-17(28-10-12)19(23,24)25/h1-4,9-10,15H,5-8,11H2,(H,26,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242070 (US9415055, 2-chloro-N-[2-(4,4-difluoro-1-piperidyl...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H18ClF5N4O/c20-14-4-2-1-3-13(14)16(30)26-11-15(29-7-5-18(21,22)6-8-29)12-9-27-17(28-10-12)19(23,24)25/h1-4,9-10,15H,5-8,11H2,(H,26,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair