BDBM242071 US9415055, 2,3-dichloro-N-[2-(4,4-difluoro-1-piperidyl)-2-(2-methylpyrimidin-5-yl)ethyl]benzamide::US9593105, 164

SMILES: Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCC(F)(F)CC1

InChI Key: InChIKey=XWNYPOVDIBCDKT-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 242071   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242071 (US9415055, 2,3-dichloro-N-[2-(4,4-difluoro-1-piper...) Show SMILES Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H20Cl2F2N4O/c1-12-24-9-13(10-25-12)16(27-7-5-19(22,23)6-8-27)11-26-18(28)14-3-2-4-15(20)17(14)21/h2-4,9-10,16H,5-8,11H2,1H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242071 (US9415055, 2,3-dichloro-N-[2-(4,4-difluoro-1-piper...) Show SMILES Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H20Cl2F2N4O/c1-12-24-9-13(10-25-12)16(27-7-5-19(22,23)6-8-27)11-26-18(28)14-3-2-4-15(20)17(14)21/h2-4,9-10,16H,5-8,11H2,1H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242071 (US9415055, 2,3-dichloro-N-[2-(4,4-difluoro-1-piper...) Show SMILES Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H20Cl2F2N4O/c1-12-24-9-13(10-25-12)16(27-7-5-19(22,23)6-8-27)11-26-18(28)14-3-2-4-15(20)17(14)21/h2-4,9-10,16H,5-8,11H2,1H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242071 (US9415055, 2,3-dichloro-N-[2-(4,4-difluoro-1-piper...) Show SMILES Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CCC(F)(F)CC1 Show InChI InChI=1S/C19H20Cl2F2N4O/c1-12-24-9-13(10-25-12)16(27-7-5-19(22,23)6-8-27)11-26-18(28)14-3-2-4-15(20)17(14)21/h2-4,9-10,16H,5-8,11H2,1H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair