BDBM242093 US9415055, (+)2-chloro-N-[2-(4,4-difluoro-1-piperidyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]-3-fluoro-benzamide::US9593105, 95

SMILES: Fc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cnc(nc2)C(F)(F)F)c1Cl

InChI Key: InChIKey=CKDQRIJGYPDNED-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 242093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242093 (US9415055, (+)2-chloro-N-[2-(4,4-difluoro-1-piperi...) Show SMILES Fc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cnc(nc2)C(F)(F)F)c1Cl Show InChI InChI=1S/C19H17ClF6N4O/c20-15-12(2-1-3-13(15)21)16(31)27-10-14(30-6-4-18(22,23)5-7-30)11-8-28-17(29-9-11)19(24,25)26/h1-3,8-9,14H,4-7,10H2,(H,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242093 (US9415055, (+)2-chloro-N-[2-(4,4-difluoro-1-piperi...) Show SMILES Fc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cnc(nc2)C(F)(F)F)c1Cl Show InChI InChI=1S/C19H17ClF6N4O/c20-15-12(2-1-3-13(15)21)16(31)27-10-14(30-6-4-18(22,23)5-7-30)11-8-28-17(29-9-11)19(24,25)26/h1-3,8-9,14H,4-7,10H2,(H,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242093 (US9415055, (+)2-chloro-N-[2-(4,4-difluoro-1-piperi...) Show SMILES Fc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cnc(nc2)C(F)(F)F)c1Cl Show InChI InChI=1S/C19H17ClF6N4O/c20-15-12(2-1-3-13(15)21)16(31)27-10-14(30-6-4-18(22,23)5-7-30)11-8-28-17(29-9-11)19(24,25)26/h1-3,8-9,14H,4-7,10H2,(H,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair