BDBM242109 US9415055, 2,3-dichloro-N-(2-(2-methylpyrimidin-5-yl)-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethyl)benzamide::US9593105, 110

SMILES: Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CC(F)(F)C(F)(F)C1

InChI Key: InChIKey=GIZNNAFXEWWKND-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242109   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242109 (US9415055, 2,3-dichloro-N-(2-(2-methylpyrimidin-5-...) Show SMILES Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CC(F)(F)C(F)(F)C1 Show InChI InChI=1S/C18H16Cl2F4N4O/c1-10-25-5-11(6-26-10)14(28-8-17(21,22)18(23,24)9-28)7-27-16(29)12-3-2-4-13(19)15(12)20/h2-6,14H,7-9H2,1H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242109 (US9415055, 2,3-dichloro-N-(2-(2-methylpyrimidin-5-...) Show SMILES Cc1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)N1CC(F)(F)C(F)(F)C1 Show InChI InChI=1S/C18H16Cl2F4N4O/c1-10-25-5-11(6-26-10)14(28-8-17(21,22)18(23,24)9-28)7-27-16(29)12-3-2-4-13(19)15(12)20/h2-6,14H,7-9H2,1H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair