BDBM242148 US9415055, (-)2,3-dichloro-N-[2-(4,4-difluoro-1-piperidyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]-5-fluoro-benzamide::US9593105, 150

SMILES: Fc1cc(Cl)c(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(nc1)C(F)(F)F

InChI Key: InChIKey=LHLUGFCNLGOCSR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 242148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242148 (US9415055, (-)2,3-dichloro-N-[2-(4,4-difluoro-1-pi...) Show SMILES Fc1cc(Cl)c(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(nc1)C(F)(F)F Show InChI InChI=1S/C19H16Cl2F6N4O/c20-13-6-11(22)5-12(15(13)21)16(32)28-9-14(31-3-1-18(23,24)2-4-31)10-7-29-17(30-8-10)19(25,26)27/h5-8,14H,1-4,9H2,(H,28,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242148 (US9415055, (-)2,3-dichloro-N-[2-(4,4-difluoro-1-pi...) Show SMILES Fc1cc(Cl)c(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(nc1)C(F)(F)F Show InChI InChI=1S/C19H16Cl2F6N4O/c20-13-6-11(22)5-12(15(13)21)16(32)28-9-14(31-3-1-18(23,24)2-4-31)10-7-29-17(30-8-10)19(25,26)27/h5-8,14H,1-4,9H2,(H,28,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242148 (US9415055, (-)2,3-dichloro-N-[2-(4,4-difluoro-1-pi...) Show SMILES Fc1cc(Cl)c(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(nc1)C(F)(F)F Show InChI InChI=1S/C19H16Cl2F6N4O/c20-13-6-11(22)5-12(15(13)21)16(32)28-9-14(31-3-1-18(23,24)2-4-31)10-7-29-17(30-8-10)19(25,26)27/h5-8,14H,1-4,9H2,(H,28,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair