BDBM242182 US9415055, (-)2,3-dichloro-N-[2-(2-cyclopropylpyrimidin-5-yl)-2-(4,4-difluoro-1-piperidyl)ethyl]benzamide::US9593105, 184

SMILES: FC1(F)CCN(CC1)C(CNC(=O)c1cccc(Cl)c1Cl)c1cnc(nc1)C1CC1

InChI Key: InChIKey=OUFADCNRRLYFLU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 242182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242182 (US9415055, (-)2,3-dichloro-N-[2-(2-cyclopropylpyri...) Show SMILES FC1(F)CCN(CC1)C(CNC(=O)c1cccc(Cl)c1Cl)c1cnc(nc1)C1CC1 Show InChI InChI=1S/C21H22Cl2F2N4O/c22-16-3-1-2-15(18(16)23)20(30)28-12-17(29-8-6-21(24,25)7-9-29)14-10-26-19(27-11-14)13-4-5-13/h1-3,10-11,13,17H,4-9,12H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...				US Patent US9415055 (2016) BindingDB Entry DOI: 10.7270/Q2NC604C
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242182 (US9415055, (-)2,3-dichloro-N-[2-(2-cyclopropylpyri...) Show SMILES FC1(F)CCN(CC1)C(CNC(=O)c1cccc(Cl)c1Cl)c1cnc(nc1)C1CC1 Show InChI InChI=1S/C21H22Cl2F2N4O/c22-16-3-1-2-15(18(16)23)20(30)28-12-17(29-8-6-21(24,25)7-9-29)14-10-26-19(27-11-14)13-4-5-13/h1-3,10-11,13,17H,4-9,12H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM242182 (US9415055, (-)2,3-dichloro-N-[2-(2-cyclopropylpyri...) Show SMILES FC1(F)CCN(CC1)C(CNC(=O)c1cccc(Cl)c1Cl)c1cnc(nc1)C1CC1 Show InChI InChI=1S/C21H22Cl2F2N4O/c22-16-3-1-2-15(18(16)23)20(30)28-12-17(29-8-6-21(24,25)7-9-29)14-10-26-19(27-11-14)13-4-5-13/h1-3,10-11,13,17H,4-9,12H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...				US Patent US9593105 (2017) BindingDB Entry DOI: 10.7270/Q2R49STH
					More data for this Ligand-Target Pair