null

SMILES: NOc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1

InChI Key: InChIKey=GQQOKRQIUXMKQD-WJONJSRFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242888   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242888 (US9427442, 16) Show SMILES NOc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1 |r,c:31| Show InChI InChI=1S/C25H27F4N5O4/c26-13-5-9-15(21(30)35)16(11-12-25(27,28)29)23(36)34-22-24(37)33-20-17(8-4-10-18(20)38-31)19(32-22)14-6-2-1-3-7-14/h1-4,6-8,10,15-16,22H,5,9,11-13,31H2,(H2,30,35)(H,33,37)(H,34,36)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242888 (US9427442, 16) Show SMILES NOc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1 |r,c:31| Show InChI InChI=1S/C25H27F4N5O4/c26-13-5-9-15(21(30)35)16(11-12-25(27,28)29)23(36)34-22-24(37)33-20-17(8-4-10-18(20)38-31)19(32-22)14-6-2-1-3-7-14/h1-4,6-8,10,15-16,22H,5,9,11-13,31H2,(H2,30,35)(H,33,37)(H,34,36)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair