BDBM243205 (s)-n-(1-(3-chlorophenyl)-2-hydroxyethyl)-5,5-dimethyl-2-((tetrahydro-2h-pyran-4-yl)amino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 2

SMILES: CC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)N[C@H](CO)c1cccc(Cl)c1

InChI Key: InChIKey=OYZABGBXJPBVCZ-LJQANCHMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM243205 ((s)-n-(1-(3-chlorophenyl)-2-hydroxyethyl)-5,5-dime...) Show SMILES CC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)N[C@H](CO)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C22H28ClN5O3/c1-22(2)17-11-24-20(25-16-6-8-31-9-7-16)26-18(17)12-28(22)21(30)27-19(13-29)14-4-3-5-15(23)10-14/h3-5,10-11,16,19,29H,6-9,12-13H2,1-2H3,(H,27,30)(H,24,25,26)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...				US Patent US9546173 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q52
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