BDBM243266 7-((3-(dimethylamino)-1- piperidinyl)carbonyl)-3- (3,5-dimethyl-4-isoxazolyl)- 9-(methylsulfonyl)-9H- carbazole-1-carboxamide::US10053454, Example 10::US10196387, Example 10

SMILES: CN(C)C1CCCN(C1)C(=O)c1ccc2c(c1)n(c1c(cc(cc21)-c1c(C)noc1C)C(N)=O)S(C)(=O)=O

InChI Key: InChIKey=VVLALXNYGWGHIQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243266   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM243266 (7-((3-(dimethylamino)-1- piperidinyl)carbonyl)-3- ...) Show SMILES CN(C)C1CCCN(C1)C(=O)c1ccc2c(c1)n(c1c(cc(cc21)-c1c(C)noc1C)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C27H31N5O5S/c1-15-24(16(2)37-29-15)18-11-21-20-9-8-17(27(34)31-10-6-7-19(14-31)30(3)4)13-23(20)32(38(5,35)36)25(21)22(12-18)26(28)33/h8-9,11-13,19H,6-7,10,14H2,1-5H3,(H2,28,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...				US Patent US10053454 (2018) BindingDB Entry DOI: 10.7270/Q2C24ZFN
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM243266 (7-((3-(dimethylamino)-1- piperidinyl)carbonyl)-3- ...) Show SMILES CN(C)C1CCCN(C1)C(=O)c1ccc2c(c1)n(c1c(cc(cc21)-c1c(C)noc1C)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C27H31N5O5S/c1-15-24(16(2)37-29-15)18-11-21-20-9-8-17(27(34)31-10-6-7-19(14-31)30(3)4)13-23(20)32(38(5,35)36)25(21)22(12-18)26(28)33/h8-9,11-13,19H,6-7,10,14H2,1-5H3,(H2,28,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...				US Patent US10196387 (2019) BindingDB Entry DOI: 10.7270/Q26112DD
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM243266 (7-((3-(dimethylamino)-1- piperidinyl)carbonyl)-3- ...) Show SMILES CN(C)C1CCCN(C1)C(=O)c1ccc2c(c1)n(c1c(cc(cc21)-c1c(C)noc1C)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C27H31N5O5S/c1-15-24(16(2)37-29-15)18-11-21-20-9-8-17(27(34)31-10-6-7-19(14-31)30(3)4)13-23(20)32(38(5,35)36)25(21)22(12-18)26(28)33/h8-9,11-13,19H,6-7,10,14H2,1-5H3,(H2,28,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...				US Patent US10196387 (2019) BindingDB Entry DOI: 10.7270/Q29S1T30
					More data for this Ligand-Target Pair